Evaluation of Hirsutella sinensis mycelium for antifatigue effect.
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The present disclosure relates to extracts of Cordyceps spp. In one embodiment the Cordyceps spp. This application claims the benefit of U. Provisional Patent Application Ser. The cosmetic industry covers a wide variety of products which can include naturally or hirsutella sinensis mycelium bitcoin derived compounds for application to the skin.
Skin care compositions can be topically applied for: Cosmetics come in a variety of hirsutella sinensis mycelium bitcoin including, but not limited to: One particular area of focus in the cosmetics industry are products geared towards reducing the signs of aging. The anti-aging market is concerned with reduction or elimination of wrinkles, fine lines, age spots, hyper pigmentation, dry skin, uneven skin tone, texture, pore size, and overall radiance.
Consumers are increasingly demanding natural products and product developers are ever challenged to find formulations that contain active natural ingredients that can improve more than one sign of aging, while remaining economically feasible. As such formulations that include naturally derived hirsutella sinensis mycelium bitcoin compounds continue to be sought. Features and advantages of the invention will be apparent from the detailed description that follows, which taken in conjunction with the accompanying figures, together illustrate the features of the invention.
It is understood that these drawings merely depict exemplary results and are not, therefore, to be considered limiting in scope. Furthermore, it will be readily appreciated that the results, as generally described and illustrated in the figures herein, are averages based on clinical studies and that individual results will vary based on an individual's skin type and genetic profile.
Reference will now be made to exemplary invention embodiments and specific language will be used herein to describe the same. It will nevertheless be understood that no hirsutella sinensis mycelium bitcoin in scope is thereby intended. Alterations and further modifications of inventive features described herein, and additional applications of inventive principles which would occur to one skilled in the relevant art having possession of this disclosure, are to be considered as inventive subject matter.
Further, before particular embodiments are disclosed and described, it is to be understood that this disclosure is not limited to the particular processes and materials disclosed herein as such may vary to some degree. It is also to be understood that the terminology used herein is used for the purpose of describing particular embodiments only and is not intended to be limiting.
Such additional devices, methods, compositions, components, structures, steps, or the like, etc. Hirsutella sinensis mycelium bitcoin, amounts, hirsutella sinensis mycelium bitcoin other numerical data may be expressed or presented herein in a range format.
It is to be understood that such a range format is used merely for convenience and brevity and thus should be interpreted flexibly to include not only the numerical values explicitly recited as the limits of the range, but also to hirsutella sinensis mycelium bitcoin all the hirsutella sinensis mycelium bitcoin numerical values or sub-ranges encompassed within that range as if each numerical value and sub-range is explicitly recited.
Thus, included in this numerical range are individual values such as 0. This same principle applies to ranges reciting only one numerical value.
Furthermore, such an interpretation should apply regardless of the breadth of the range or the characteristics being described. Such changes can range from those affecting genetic and cellular function to those affecting the function of organs, organ systems, or the whole organism.
Senescence in particular refers to such changes occurring after an organism has attained biological maturity and which may progress until the eventual death of the organism. These symptoms include, but are not limited to include: Exemplary species include without limitation O. Combinations of species, anamorphs, strains, and hybrids thereof are also encompassed by such terms.
In one embodiment, cordyceps or cordyceps fungus can refer to the family of ophicordycipitaceae or a species thereof, such as Ophiocordyceps sinensis O. Accordingly, unless indicated to the contrary, the terms c. In some embodiments, extracts can be made or derived from specific parts of Cordycepssuch as the mycelium i. Extracts can take the form of a liquid, a concentrated liquid, a powder, or of raw cordyceps material in a reduced form, such as sliced, chopped, pulverized, etc. Those of ordinary skill in the art will recognize various available hirsutella sinensis mycelium bitcoin techniques.
In one embodiment, a cordyceps extract can be obtained by a process as recited in U. It is understood that various biological factors may affect the ability of a substance to perform its intended task. Further, while the achievement hirsutella sinensis mycelium bitcoin therapeutic effects may be measured by a physician or other qualified medical personnel using evaluations known in the art, it is recognized that individual variation and response to treatments may make the achievement of therapeutic effects a subjective decision.
The determination of a therapeutically effective amount or delivery rate is well within the ordinary skill in the art of pharmaceutical sciences and medicine. Extracts may take many forms including but not limited to: A wide number of extraction methods and techniques are known to those of ordinary skill in the art. In some embodiments, extracts hirsutella sinensis mycelium bitcoin be made from specific parts of a source.
In some aspects an extract may include one or more active constituents or active agents. Liquid hirsutella sinensis mycelium bitcoin can result in a liquid, suspension, slurry, particulate, dried powder or other solid or semi-solid forms derived from a source when using a liquid extract as a step in the overall extraction protocol. Liquid hirsutella sinensis mycelium bitcoin typically have a given purity percentage and can be relatively to highly pure.
In some aspects, the purity of an extract can be controlled by, or be a function of the extraction process or protocol. For example, excipients may include binders, lubricants, etc. In some embodiments, at least one ingredient may be an active agent or otherwise have properties that exert physiologic activity when administered to a subject. Various skin types and conditions specific to individual species are well known.
In one embodiment, the skin hirsutella sinensis mycelium bitcoin be mammalian skin. In a more specific embodiment, the skin may be human skin. In some embodiments, the reduction may be noticeable to the naked eye. In some instances, the reduction includes a reduction as measured using digital imaging such as, light optical profilometry, corneometers, cutometers, or ultrasound.
Changes in other physical parameters or properties, such as elasticity, hydration, lipid content and distribution, and cellular retention may also be measured using various known techniques and used as an indicator of an achievement of an effect. Achievement of an effect, such as a reduction, can take place hirsutella sinensis mycelium bitcoin a single treatment or can occur over a period of time. For example, the appearance of the reduction can be measured from a subject's appearance prior to, or at commencement e.
The exact degree of deviation allowable may in some cases depend on the specific context. Beneficial or hirsutella sinensis mycelium bitcoin results can include, but are not limited to, alleviation or amelioration of one or more signs or symptoms of a condition, stabilizing i. Such prophylactic treatment can also be referred to as prevention or prophylaxis of a condition. The hirsutella sinensis mycelium bitcoin may be partial or complete.
Partial prophylaxis may result in the delayed onset of a physiological condition. Excipients, diluents, hirsutella sinensis mycelium bitcoin other ingredients used in or used to prepare a formulation or composition for administration to a subject can be used with such term. In some instances comparison may be made to the prior art. However, these lists should be construed as though each member of the list is individually identified as a separate and unique member. Thus, no individual member of such list should be construed as a de facto equivalent of any other member of the same list solely based on their presentation in a common group without indications to the contrary.
Any steps recited in any method or process claims may be executed in any order and are not limited to the order presented in the claims unless otherwise stated. The present inventors have discovered numerous skin benefits that can be achieved through application and use of topical formulations that include a Cordyceps extract.
Such benefits can include without limitation, reduced presence and visibility of fine lines and wrinkles, improved skin elasticity and hydration, improved color, and improved texture and skin tone among others. Also discovered is the importance of the specific content of the Cordyceps extract used in the topical formulations. Further discovered is the value of a routine or regimen in guiding application and use of the topical formulation.
In one embodiment, the adenosine content can be from about 0. In another embodiment, the adenosine content can be from about 0. Various Cordyceps species can be used as the extract source. However, in one aspect, the Cordyceps extract can be derived from a member selected from the group consisting of: In one embodiment, the Cordyceps extract is derived from C.
In another embodiment, the Cordyceps extract is derived from C. In yet another embodiment, the Cordyceps extract is derived from C. The extract can be derived from any part of the Cordyceps fungus as previously mentioned. In one embodiment, the extract can be derived from whole ground mushrooms. In another embodiment, the adenosine content in the extract can be greater than about 0.
In yet another embodiment the amount can be from about 0. The extract can take various forms and be a liquid extract, a powder extract, a compound, or a mixture thereof. In some embodiments, the extract can be soluble in water. Also presented herein, are topical formulations that hirsutella sinensis mycelium bitcoin a Cordyceps extract.
In one embodiment, the adenosine content is hirsutella sinensis mycelium bitcoin least about 0. The concentration of the Cordyceps extract in the formulation can vary.
In one embodiment, the extract can be present in the formulation in an amount of from about 0. In another embodiment, the Cordyceps extract can be present in the formulation in an amount of from about 0. In another embodiment the Cordyceps extract can be present in the formulation in an amount of from about 0. The Cordyceps extract can take any form as described herein.
A wide variety of pharmaceutical carriers that are suitable for preparation of a topical formulation can be included in the present formulations. The pharmaceutically acceptable carrier can be physiologically inert and non-toxic. In some embodiments, the pharmaceutically acceptable carrier can be a pharmaceutical hirsutella sinensis mycelium bitcoin compound.
A number of suitable volatile solvents or solvent components can be used and can aid in maintaining the formulation in a desired physical form prior to application to the skin. In hirsutella sinensis mycelium bitcoin embodiment, the volatile solvent can be included in the formulation in an amount of greater than about can comprise at least one of denatured alcohol, ethanol, hexane, methyl ethyl ketone, methanol, propanol, isobutene, pentane, water, and combinations thereof.
In another embodiment, the volatile solvent can comprise water. In one embodiment, the water can be deionized. A variety of non-volatile solvents can be utilized in the present formulations and can aid in loading of active agents or active fractions into the formulation and maintaining such agents or fractions in a solubilized form that is suitable for topical administration and absorption. Additionally, such solvents can aid in enhancing penetration of the active agents or fractions into the skin.
